Fig. 5.

The effect of STZ-induced hyperglycemia on long-term hippocampal function as measured by the Barnes maze behavioral test on P90. Hole pokes made by animal on the maze during probe trials (schematic is shown in Fig. 1), with goal location represented in the center and subsequent holes moving progressively away from the goal (a). Quantified “good guesses” represented by hole pokes nearest the goal location compared with “bad guesses” represented by hole pokes furthest from the goal location, demonstrating that hyperglycemia group (gray) made fewer “good” and more “bad” guesses compared with the control group (black) (b), *p < 0.05