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. 2018 Mar 15;12:3. doi: 10.1186/s13036-018-0094-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Serotonin production using a two-stage strategy. a and d growth curves; (b and e) production/consumption of tryptophan, 5HTP and serotonin. Side reaction (tryptophan conversion to tryptamine) is also indicated in panel e. with dashed lines; c and f HPLC retention pattern of tryptophan, 5HTP and serotonin; (a, b and c) panels correspond to the TrpD-Pl / pACJ23-CtAAAH-LC fermentation for the production of 5HTP from glucose; panels (d, e and f) correspond to the BL21(DE3) ΔtnaA / pCOLAJ23-TDC fermentation for the production of serotonin. Values in the graph are the average of triplicates, error bars correspond to the standard error of the mean (SEM)