Table 1. Body, white adipocyte tissue (WAT), liver, heart, lung, and kidney weight of high-fat diet (HFD)-fed mice.

	ND	HFD	HFD+Rg1-300	HFD+Rg1-500	P-valuea	P-valueb	P-valuec
Initial body weight (g)	23.1±1.0	23.3±0.8	23.3±1.2	23.3±1.2	ns	ns	ns
Final body weight (g)	28.5±1.0	39.9±1.7	34.9±1.2	31.8±0.9	P<0.001	P<0.001	P<0.001
Body weight gain (g)	5.4±0.8	16.6±0.8	11.7±0.7	8.9±0.9	P<0.001	P<0.001	P<0.001
WAT (g)	0.70±0.103	3.11±0.32	1.68±0.33	1.05±0.36	P<0.001	P<0.001	P<0.001
Liver (g)	0.80±0.11	1.20±0.16	0.97±0.12	0.87±0.12	P<0.001	P<0.001	P<0.001
Heart (g)	0.130±0.007	0.132±0.005	0.134±0.006	0.131±0.005	ns	ns	ns
Lung (g)	0.140±0.014	0.143±0.009	0.141±0.007	0.142±0.007	ns	ns	ns
Kidney (g)	0.180±0.012	0.181±0.015	0.183±0.016	0.185±0.011	ns	ns	ns
Fasting glucose (mg/dL)	91.8±11.9	151.4±16.2	119.0±8.0	99.0±6.6	P<0.001	P<0.001	P<0.001

Seven-week-old male C57BL/6J mice were fed with either ND (normal diet) or HFD (high-fat diet). The HFD-fed mice were treated with or without Rg1 at a dose of 300 mg·kg^-1·day^-1 (Rg1-300) or 500 mg·kg^-1·day^-1 (Rg1-500) for 2 months. Initial and final body weight of mice was measured. The weight of liver, heart, lung, and kidney as well as fasting glucose was measured. Data are reported as means±SE (n=8).

^aComparison between ND group and HFD group;

^bComparison between HFD group and HFD + Rg1-300 group;

^cComparison between HFD group and HFD + Rg1-500 group (one-way ANOVA followed by Dunnett’s post hoc test). ns: not significant.