REAGENT or RESOURCE	SOURCE	IDENTIFIER
Bacterial and Virus Strains
ArcticExpress (DE3) competent E.coli	Agilent	Cat#230192
Chemicals, Peptides, and Recombinant Proteins
Brequinar sodium salt hydrate	Sigma Aldrich	Cat#SML0113
n-Dodecyl-N,N-Dimethylamine-N-Oxide (LDAO)	Anatrace	Cat#D360
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE)	Avanti Polar Lipids	Cat#850757P
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)	Avanti Polar Lipids	Cat#850457P
1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (CDL)	Avanti Polar Lipids	Cat#710335P
Dimethylsulfoxide (DMSO)	Sigma Aldrich	Cat#276855
Ammonium acetate	Sigma Aldrich	Cat#5.43834
H. sapiens DHODHNΔ30	Ullrich et al., 2001	N/A
3,4-Dimethoxy-5-Methyl-p-Benzoquinone	Sigma Aldrich	Cat#D9150
Deposited Data
Crystal structure of hDHODH with 3-amido-5-biphenyl-benzoic acid	Hurt et al., 2006	PDB: 2B0M https://www.rcsb.org/pdb/explore/explore.do?structureId=2B0M
Crystal structure of hDHODH with brequinar analogue	Liu et al., 2000	PDB: 1D3G https://www.rcsb.org/pdb/explore/explore.do?structureId=1d3g
Crystal structure of ligand-free DHODH	Walse et al., 2008	PDB: 2PRM https://www.rcsb.org/pdb/explore/explore.do?structureId=2prm
Recombinant DNA
pNIC28-Bsa4	Savitsky et al., 2010	Addgene plasmid # 26103
H. sapiens DHODHNΔ30 coding sequence (Liu et al., 2000)	GeneArt	N/A
Software and Algorithms
PULSAR	Allison et al., 2015	http://www.pulsar.chem.ox.ac.uk
UniDec	Marty et al., 2015	http://www.unidec.chem.ox.ac.uk
IMPACT	Marklund et al., 2015	http://www.impact.chem.ox.ac.uk
mMass	Strohalm et al., 2010	http://www.mmass.org
Xcalibur	Thermo Scientific	N/A
UCSF Chimera v1.11.02	Pettersen et al., 2004	http://www.cgl.ucsf.edu/chimera
PyMol	Schrödinger, LLC Version 1.8	www.sourceforge.net/projects/pymol
GROMACS 2016.1	Abraham et al., 2015	http://www.gromacs.org
MemGen	Knight and Hub, 2015	http://memgen.uni-goettingen.de
ModLoop	Fiser and Sali, 2003	https://modbase.compbio.ucsf.edu/modloop/
AMBER99SB-ILDN force field	Lindorff-Larsen et al., 2010	http://ambermd.org/#ff
FMN force field parameters	Schneider and Sühnel, 1999	http://research.bmh.manchester.ac.uk/bryce/amber
POPE force field parameters and coordinates	Jämbeck and Lyubartsev, 2012b	http://www.fos.su.se/∼sasha/SLipids/Downloads.html
Other
Medium nanoES capillaries	Thermo Scientific	Cat#ES380