Table 3. Distribution of semen and hormonal parameters according to the presence or non-presence of MS.
| FM-MS - | FM -MS + | MPIC-MS - | MPIC-MS + | P | |
|---|---|---|---|---|---|
| (n = 209) | (n = 29) | (n = 2171) | (n = 471) | mean | |
| Semen volume (mL) | |||||
| AMean(95%CI) | 3.7(3.5; 4.0) | 4 4.2(3.5; 5.0) | 3.9(3.8; 4.0) | 3.6(3.5; 3.8) | .052 |
| Sperm concentration (×106/mL) | |||||
| AMean(95%CI) | 77.7(69.9; 86.3) | 55.9(41.4; 75.4) | 37.8(35.8; 40.0) | 40.0(36.5; 45.9) | < .001d, e |
| Total sperm count (×106) | |||||
| AMean(95%CI) | 289.5(257.8;325.1) | 234.9(175.2;314.5) | 144.3(136.3;152.6) | 142.9(126.1;162.1) | < .001 d, e |
| Motile spermatozoa (%) | |||||
| AMean(95%CI) | 51.5(49.9; 53.2) | 51.8(48.3; 55.4) | 41.5(40.8; 42.1) | 40.9(39.4; 42.4) | < .001 d, e, f, g |
| Normal morphology (%) | |||||
| Mean(95%CI) | 11.2(10.5; 12.0) | 9.2(7.3; 11.2) | 7.0(6.7; 7.2) | 6.9(6.4; 7.4) | < .001 d, e |
| Serum FSH (IU/L) | |||||
| Mean(95%CI) | 4.2(3.8; 4.6) | 4.0(3.3; 5.1) | 4.3(4.2; 4.5) | 4.3(4.0; 4.6) | .917 |
| Serum LH (IU/L) | |||||
| Mean(95%CI) | 3.7(3.4; 3.9) | 4.2(3.6; 4.9) | 3.6(3.5; 3.7) | 3.3(3.1; 3.5) | .004 c |
| Testosterone (nmol/L) | |||||
| Mean(95%CI) | 17.3(16.5; 18.1) | 13.5(11.4; 15.7) | 17.4(17.2; 17.7) | 13.2(12.5; 13.8) | < .001 a, b, e |
| Oestradiol (pmol/L) | |||||
| Mean(95%CI) | 124.0(117.2;130.9) | 120.8(101.0;140.4) | 130.6(127.7; 133.5) 134.4(129.0; 139.9) | 139.6(133.5; 145.7) | .007 e |
Reproductive parameters were adjusted for study age, alcohol use, smoking and TTV.
a Post-hoc pairwise comparisons with Bonferroni correction revealed P <0.001 FM-MS—versus FM-MS+
b Post-hoc pairwise comparisons with Bonferroni correction revealed P <0.001 MPIC-MS—versus MPIC-MS+
c Post-hoc pairwise comparisons with Bonferroni correction revealed P <0.05 MPIC-MS—versus MPIC-MS+
d Post-hoc pairwise comparisons with Bonferroni correction revealed P <0.01 FM-MS—versus MPIC-MS-
e Post-hoc pairwise comparisons with Bonferroni correction revealed P <0.01 FM-MS—versus MPIC-MS+
f Post-hoc pairwise comparisons with Bonferroni correction revealed P <0.01 FM-MS + versus MPIC- MS-
g Post-hoc pairwise comparisons with Bonferroni correction revealed P <0.01 FM-MS + versus MPIC- MS+