Fig. 1.

Modular architectures of vertebrate galectins (A) including prototype, tandem-repeat, and monomeric chimera-type proteins. Illustration of the natural forms of Gal-1 (B), Gal-4 (C), Gal-8 (D), and Gal-3 (E), as well as engineered variants and the separate CRDs derived from in situ proteolytic cleavage. N and C indicate type of CRD positioning relative to the termini. Numbers indicate length (amino acid, AA) of linkers between CRDs, while * denotes the site of the sequence deviation in the human SNP variant protein F19Y.