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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Mol Aspects Med. 2017 Oct 10;60:123–128. doi: 10.1016/j.mam.2017.09.006

Figure 3.

Figure 3

MicroRNAs detected in extracellular vesicles in synovial fluid of patients with osteoarthritis (OA) differ between men and women, and are secreted by fibroblast-like synoviocytes (FLS). In particular, women with OA show a marked downregulation of miR-26a, which is known to target toll-like receptors such as TLR3 in articular chondrocytes. Estrogen is known to stimulate miR-26a production, whereas estrogen inhibitors will suppress miR-23a expression [9].