. Author manuscript; available in PMC: 2019 Mar 15.

Published in final edited form as: Cell Chem Biol. 2018 Jan 4;25(3):279–290.e7. doi: 10.1016/j.chembiol.2017.12.007

Table 1. Structures and IC₅₀ values for active compounds.

IC₅₀ values were determined in a cell based growth assay with the heterozygous SEC14 deletion strain against a wildtype control, with a luminescent cell viability assay on HCT116 cells and in an in vitro lipid transfer assay, as indicated. “nd” indicates “not determined”.

Cpd	IC₅₀ [μM] S. cerevisiae wildtype	fold IC₅₀ shift S. cerevisiae wildtype/wildtypeΔ8	IC₅₀ [μM] S. cerevisiae SEC14/sec14	IC50 [μM] HCT116	IC₅₀ [μM] lipid transfer
1	13.5	13.8x	5.9	30.4	nd
2	28.5	2.7x	9.4	>100	6.7
3	6.6	2.8x	1.7	>100	0.7
4	134.9	2.3x	99.4	>100	29.4
5	42.9	2.7x	32.6	>100	30.7
6	>200	nd	>200	>100	129

Table 1. Structures and IC50 values for active compounds.

Table 1. Structures and IC₅₀ values for active compounds.