Table 3.
Results of unadjusted and adjusted logistic regression analyses that evaluated for differences in symptom occurrence rates between premenopausal and postmenopausal women 12 months after breast cancer surgery
| SYMPTOM OCCURRENCE | LOGISTIC REGRESSION RESULTS | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symptom | Occurrence rate % | Covariate | Unadjusted Model | Adjusted Model | |||||
| PRE (n=115) |
POST (n=212) |
OR | CI | p-value | OR | CI | p-value | ||
| Eating more than usual | 25.0 | 12.3 | Overall Model X2=19.33; p=.036 |
||||||
| Menopausal status* | 0.41 | 0.23, 0.75 | .004 | 0.43 | 0.19, 1.00 | .050 | |||
| Age (in 5 year increments) | 0.95 | 0.79, 1.14 | .565 | ||||||
| Lives alone | 0.72 | 0.32, 1.62 | .429 | ||||||
| Working for pay | 0.75 | 0.4, 1.42 | .384 | ||||||
| SCQ score | 1.13 | 1.00, 1.26 | .044 | ||||||
| Prior HRT | 0.86 | 0.32, 2.28 | .761 | ||||||
| Adjuvant chemotherapy during 12 months | 1.30 | 0.68, 2.47 | .425 | ||||||
| Radiation therapy during 12 months | 1.33 | 0.58, 3.01 | .501 | ||||||
| Reconstruction during 12 months | 0.85 | 0.29, 2.49 | .771 | ||||||
| Type of surgery: conservation (ref) vs mastectomy | 2.08 | 0.82, 5.27 | .125 | ||||||
| Skin breakout/acne | 17.2 | 7.1 | Overall Model X2=24.11; p=.007 |
||||||
| Menopausal status* | 0.39 | 0.19, 0.79 | .009 | 1.00 | 0.38, 2.66 | .999 | |||
| Age (in 5 year increments) | 0.71 | 0.56, 0.89 | .003 | ||||||
| Lives alone | 2.58 | 1.09, 6.1 | .031 | ||||||
| Working for pay | 1.33 | 0.6, 2.92 | .480 | ||||||
| SCQ score | 1.06 | 0.91, 1.24 | .450 | ||||||
| Prior HRT | 0.71 | 0.18, 2.69 | .610 | ||||||
| Adjuvant chemotherapy during 12 months | 1.12 | 0.51, 2.45 | .786 | ||||||
| Radiation therapy during 12 months | 0.73 | 0.29, 1.86 | .514 | ||||||
| Reconstruction during 12 months | 1.40 | 0.43, 4.59 | .577 | ||||||
| Type of surgery: conservation (ref) vs mastectomy | 1.20 | 0.39, 3.68 | .745 | ||||||
| Hostility | 16.5 | 7.1 | Overall Model X2=15.12; p=.128 |
||||||
| Menopausal status* | 0.38 | 0.19, 0.79 | .009 | 0.59 | 0.23, 1.54 | .284 | |||
| Age (in 5 year increments) | 0.77 | 0.62, 0.96 | .021 | ||||||
| Lives alone | 0.96 | 0.36, 2.52 | .926 | ||||||
| Working for pay | 0.85 | 0.40, 1.80 | .667 | ||||||
| SCQ score | 1.09 | 0.94, 1.26 | .240 | ||||||
| Prior HRT | 1.56 | 0.51, 4.75 | .433 | ||||||
| Adjuvant chemotherapy during 12 months | 0.83 | 0.38.1.82 | .637 | ||||||
| Radiation therapy during 12 months | 1.54 | 0.55, 4.25 | .410 | ||||||
| Reconstruction during 12 months | 1.31 | 0.36, 4.83 | .680 | ||||||
| Type of surgery: conservation (ref) vs mastectomy | 1.05 | 0.31, 3.54 | .940 | ||||||
| Weight gain | 37.1 | 24.6 | Overall Model X2=17.02; p=.074 |
||||||
| Menopausal status* | 0.57 | 0.35, 0.93 | .025 | 0.94 | 0.48, 1.83 | .846 | |||
| Age (in 5 year increments) | 0.87 | 0.75, 1.01 | .062 | ||||||
| Lives alone | 0.99 | 0.53, 1.84 | .963 | ||||||
| Working for pay | 0.99 | 0.59, 1.66 | .980 | ||||||
| SCQ score | 1.01 | 0.92, 1.12 | .798 | ||||||
| Prior HRT | 0.64 | 0.29, 1.38 | .254 | ||||||
| Adjuvant chemotherapy during 12 months | 1.38 | 0.82, 2.34 | .228 | ||||||
| Radiation therapy during 12 months | 1.50 | 0.76, 2.98 | .241 | ||||||
| Reconstruction during 12 months | 0.82 | 0.32, 2.09 | .680 | ||||||
| Type of surgery: conservation (ref) vs mastectomy | 1.60 | 0.72, 3.6 | .251 | ||||||
| Irritability | 41.7 | 29.7 | Overall Model X2=12.25; p=.269 |
||||||
| Menopausal status | 0.58 | 0.36, 0.94 | .027 | 0.60 | 0.32, 1.15 | .1 26 | |||
| Age (in 5 year increments) | 0.94 | 0.82, 1.07 | .342 | ||||||
| Lives alone | 0.98 | 0.55, 1.75 | .939 | ||||||
| Working for pay | 0.93 | 0.57, 1.51 | .769 | ||||||
| SCQ score | 1.07 | 0.98, 1.17 | .144 | ||||||
| Prior HRT | 1.13 | 0.58, 2.20 | .714 | ||||||
| Adjuvant chemotherapy during 12 months | 0.90 | 0.54, 1.50 | .684 | ||||||
| Radiation therapy during 12 months | 1.63 | 0.85, 3.10 | .140 | ||||||
| Reconstruction during 12 months | 0.78 | 0.32, 1.91 | .588 | ||||||
| Type of surgery: conservation (ref) vs mastectomy | 1.85 | 0.86, 4.00 | .117 | ||||||
| Lost sexual interest | 22.4 | 13.7 | Overall Model X2 =26.27; p=.003 |
||||||
| Menopausal status* | 0.54 | 0.30, 0.98 | .039 | 1.18 | 0.53, 2.59 | .687 | |||
| Age (in 5 year increments) | 0.77 | 0.64, 0.92 | .005 | ||||||
| Lives alone | 0.18 | 0.05, 0.60 | .005 | ||||||
| Working for pay | 0.92 | 0.49, 1.71 | .784 | ||||||
| SCQ score | 1.03 | 0.91, 1.16 | .680 | ||||||
| Prior HRT | 1.30 | 0.53, 3.2 | .571 | ||||||
| Adjuvant chemotherapy during 12 months | 0.99 | 0.52, 1.91 | .987 | ||||||
| Radiation therapy during 12 months | 0.69 | 0.31, 1.56 | .377 | ||||||
| Reconstruction during 12 months | 1.18 | 0.4, 3.51 | .763 | ||||||
| Type of surgery: conservation (ref) or mastectomy | 0.61 | 0.22, 1.72 | .353 | ||||||
Abbreviations: CI = confidence interval; HRT = hormone replacement therapy; OR = odds ratio; PRE = premenopausal; POST = postmenopausal; ref = reference group; SCQ = Self-administered Comorbidity Questionnaire; vs = versus
*
reference group = premenopausal women