Table 4.
Results of unadjusted and adjusted logistic regression analyses that evaluated for differences between premenopausal and postmenopausal women in symptom occurrence rates with interaction effects 12 months after breast cancer surgery
| LOGISTIC REGRESSION RESULTS | |||||||
|---|---|---|---|---|---|---|---|
| Symptom | Covariates | Unadjusted Model | Adjusted Model | ||||
| OR | CI | p-value | OR | CI | p-value | ||
| Logistic Regression Results for Total Sample | |||||||
| Hot flashes PRE = 58.3% POST = 45.3% |
Overall Model X2=59.53; p<.001 |
||||||
| Menopausal status* | 0.56 | 0.35, 0.89 | .015 | 5681.12 | 136.43, 236576.94 | <.001 | |
| Age (in 5 year increments) | 1.38 | 1.00, 1.92 | .050 | ||||
| Lives alone | 0.92 | 0.51, 1.65 | .770 | ||||
| Working for pay | 0.65 | 0.39, 1.07 | .089 | ||||
| SCQ score | 1.07 | 0.97, 1.17 | .188 | ||||
| Prior HRT | 2.19 | 1.1 0, 4.36 | .026 | ||||
| Adjuvant chemotherapy during 12 months | 1.11 | 0.66, 1.87 | .692 | ||||
| Radiation therapy during 12 months | 1.11 | 0.59, 2.1 0 | .739 | ||||
| Reconstruction during 12 months | 1.52 | 0.63, 3.68 | .352 | ||||
| Type of surgery: conservation (ref) vs mastectomy | 0.96 | 0.44, 2.1 0 | .921 | ||||
| Age × menopausal status | 0.42 | 0.29, 0.61 | .000 | ||||
| Adjusted Regression of Hot Flashes Occurrence on Age, Stratified by Menopausal Status | |||||||
| Premenopausal | 1.43 | 0.99, 2.06 | .055 | ||||
| Postmenopausal | 0.56 | 0.46, 0.69 | <.001 | ||||
| Night Sweats PRE = 44.3% POST = 32.5% |
Overall Model X2=41.70; p<.001 |
||||||
| Menopausal status* | 0.59 | 0.37, 0.94 | .026 | 1132.50 | 29.38, 43655.1 | <.001 | |
| Age (in 5 year increments) | 1.3 0 | 0.94, 1.8 0 | .117 | ||||
| Lives alone | 1.05 | 0.57, 1.92 | .872 | ||||
| Working for pay | 0.97 | 0.59, 1.59 | .892 | ||||
| SCQ score | 1.04 | 0.95, 1.15 | .397 | ||||
| Prior HRT | 2.35 | 1.18, 4.67 | .015 | ||||
| Adjuvant chemotherapy during 12 months | 1.04 | 0.62, 1.75 | .872 | ||||
| Radiation therapy during 12 months | 0.85 | 0.45, 1.62 | .632 | ||||
| Reconstruction during 12 months | 0.91 | 0.38, 2.2 0 | .837 | ||||
| Type of surgery: conservation (ref) vs mastectomy | 1.28 | 0.58, 2.82 | .536 | ||||
| Age × menopausal status | 0.49 | 0.34, 0.71 | <.001 | ||||
| Adjusted Regression of Night Sweats Occurrence on Age, Stratified by Menopausal Status | |||||||
| Premenopausal | 1.31 | 0.92, 1.88 | .140 | ||||
| Postmenopausal | 0.63 | 0.52, 0.76 | <.001 | ||||
| Depression PRE = 34.5% POST = 24.5% |
Overall Model X2 =30.92; p=.001 |
||||||
| Menopausal status* | 0.60 | 0.37, 0.99 | .047 | 338.93 | 6.92, 16611.16 | .003 | |
| Age (in 5 year increments) | 1.41 | 0.98, 2.02 | .061 | ||||
| Lives alone | 0.89 | 0.47, 1.71 | .733 | ||||
| Working for pay | 1.02 | 0.60, 1.73 | .937 | ||||
| SCQ score | 1.18 | 1.07, 1.30 | .001 | ||||
| Prior HRT | 0.83 | 0.39, 1.76 | .620 | ||||
| Adjuvant chemotherapy during 12 months | 1.04 | 0.60, 1.79 | .889 | ||||
| Radiation therapy during 12 months | 0.82 | 0.42, 1.61 | .571 | ||||
| Reconstruction during 12 months | 1.19 | 0.47, 2.98 | .717 | ||||
| Type of surgery: conservation (ref) vs mastectomy | 1.16 | 0.51, 2.64 | .725 | ||||
| Age × menopausal status | 0.54 | 0.36, 0.8 0 | .002 | ||||
| Adjusted Regression of Depression Occurrence on Age, Stratified by Menopausal Status | |||||||
| Premenopausal | 1.50 | 1.00, 2.25 | .048 | ||||
| Postmenopausal | 0.77 | 0.64, 0.92 | .003 | ||||
| Daytime sweats PRE = 39.7% POST = 26.9% |
Overall Model X2=34.535; p=.011 |
||||||
| Menopausal status* | 0.53 | 0.33, 0.87 | .011 | 137.20 | 3.53, 5329.31 | .008 | |
| Age (in 5 year increments) | 1.3 0 | 0.93, 1.83 | .121 | ||||
| Lives alone | 0.78 | 0.42, 1.47 | .446 | ||||
| Working for pay | 0.91 | 0.54, 1.51 | .705 | ||||
| SCQ score | 1.08 | 0.98, 1.19 | .122 | ||||
| Prior HRT | 2.92 | 1.46, 5.83 | .002 | ||||
| Adjuvant chemotherapy during 12 months | 0.98 | 0.57, 1.66 | .931 | ||||
| Radiation therapy during 12 months | 1.21 | 0.61, 2.39 | .581 | ||||
| Reconstruction during 12 months | 0.62 | 0.24, 1.56 | .308 | ||||
| Type of surgery: conservation (ref) vs mastectomy | 2.18 | 0.97, 4.93 | .060 | ||||
| Age × menopausal status | 0.57 | 0.39, 0.83 | .004 | ||||
| Adjusted Regression of Daytime Sweats Occurrence on Age, Stratified by Menopausal Status | |||||||
| Premenopausal | 1.27 | 0.89, 1.81 | .190 | ||||
| Postmenopausal | 0.74 | 0.63, 0.89 | .001 | ||||
| Joint pain or stiffness PRE = 40.0% POST = 51.9% |
Overall Model X2=23.66; p=.014 |
||||||
| Menopausal status* | 1.62 | 1.02, 2.57 | .043 | 387.32 | 6.64, 22601.80 | .004 | |
| Age (in 5 year increments) | 1.88 | 1.26, 2.79 | .002 | ||||
| Lives alone | 0.97 | 0.56, 1.68 | .906 | ||||
| Working for pay | 0.89 | 0.55, 1.42 | .614 | ||||
| SCQ score | 1.07 | 0.98, 1.17 | .133 | ||||
| Prior HRT | 1.00 | 0.54, 1.86 | .993 | ||||
| Adjuvant chemotherapy during 12 months | 1.40 | 0.85, 2.32 | .188 | ||||
| Radiation therapy during 12 months | 0.63 | 0.34, 1.17 | .145 | ||||
| Reconstruction during 12 months | 1.31 | 0.54, 3.16 | .551 | ||||
| Type of surgery: conservation (ref) vs mastectomy | 0.61 | 0.28, 1.31 | .206 | ||||
| Age × menopausal status | 0.54 | 0.36, 0.83 | .004 | ||||
| Adjusted Regression of Joint Pain Occurrence on Age, Stratified by Menopausal Status | |||||||
| Premenopausal | 2.07 | 1.33, 3.23 | .001 | ||||
| Postmenopausal | 1.00 | 0.86, 1.15 | .947 | ||||
| Wake during the night PRE = 61.7% POST = 63.7% |
Overall Model X2=23.12; p=.017 |
||||||
| Menopausal status* | 1.08 | 0.67, 1.73 | .764 | 149.89 | 4.59, 4893.95 | .005 | |
| Age (in 5 year increments) | 1.25 | 0.91, 1.72 | .170 | ||||
| Lives alone | 0.92 | 0.52, 1.63 | .779 | ||||
| Working for pay | 0.64 | 0.39, 1.05 | .079 | ||||
| SCQ score | 1.10 | 1.00, 1.21 | .058 | ||||
| Prior HRT | 1.29 | 0.67, 2.48 | .447 | ||||
| Adjuvant chemotherapy during 12 months | 0.90 | 0.53, 1.51 | .678 | ||||
| Radiation therapy during 12 months | 1.06 | 0.57, 1.97 | .855 | ||||
| Reconstruction during 12 months | 2.53 | 0.99, 6.47 | .052 | ||||
| Type of surgery: conservation (ref) vs mastectomy | 0.7 0 | 0.32, 1.54 | .380 | ||||
| Age × menopausal status | 0.62 | 0.44, 0.88 | .008 | ||||
| Adjusted Regression of Wake During the Night Occurrence on Age, Stratified by Menopausal Status | |||||||
| Premenopausal | 1.29 | 0.92, 1.80 | .142 | ||||
| Postmenopausal | 0.76 | 0.64, 0.90 | .001 | ||||
| Numbness or tingling PRE = 27.8% POST = 29.7% |
Overall Model X2=29.37; p=.002 |
||||||
| Menopausal status* | 1.12 | 0.67, 1.86 | .673 | 174.64 | 3.33, 9171.79 | .011 | |
| Age (in 5 year increments) | 1.29 | 0.89, 1.87 | .185 | ||||
| Lives alone | 1.52 | 0.83, 2.79 | .174 | ||||
| Working for pay | 0.74 | 0.44, 1.24 | .253 | ||||
| SCQ score | 1.08 | 0.98, 1.18 | .143 | ||||
| Prior HRT | 1.05 | 0.52, 2.12 | .900 | ||||
| Adjuvant chemotherapy during 12 months | 2.47 | 1.45, 4.20 | .001 | ||||
| Radiation therapy during 12 months | 0.82 | 0.42, 1.6 0 | .562 | ||||
| Reconstruction during 12 months | 1.06 | 0.42, 2.67 | .905 | ||||
| Type of surgery: conservation (ref) vs mastectomy | 1.16 | 0.52, 2.6 0 | .710 | ||||
| Age × menopausal status | 0.62 | 0.41, 0.92 | .019 | ||||
| Adjusted Regression of Numbness or Tingling Occurrence on Age, Stratified by Menopausal Status | |||||||
| Premenopausal | 1.32 | 0.88, 1.98 | .176 | ||||
| Postmenopausal | 0.79 | 0.66, 0.93 | .006 | ||||
Abbreviations: CI = confidence interval; HRT = hormone replacement therapy; OR = odds ratio; PRE = premenopausal; POST = postmenopausal; ref = reference group; SCQ = Self-administered Comorbidity Questionnaire; vs = versus
*
reference group = premenopausal women