. Author manuscript; available in PMC: 2019 Apr 1.

Published in final edited form as: J Pharm Sci. 2017 Dec 14;107(4):1194–1203. doi: 10.1016/j.xphs.2017.12.004

Table 1.

Model independent and model predicted CDF clearance (mL/min) across Caco-2 cells following apical (AB transport direction) or basolateral (BA transport direction) exposure to 5 μM CDF.

Model Independent Analysis		Model Based Analysis

AB	BA	Estimate	AB	BA	AB/BA Combined

Mean (CV,%)	Mean (CV,%)	Population (RSE,%)	1.3 × 10⁻⁵ (19.0)	2.0 × 10⁻⁵ (10.9)	1.6 × 10⁻⁵ (11.7)

1.6 × 10⁻⁵ (30.3)	2.1 × 10⁻⁵ (3.3)	% BOFV (RSE,%)	45.1 (27.0)	18.0 (17.4)	35.7 (21.3)
1.6 × 10⁻⁵ (30.3)	2.1 × 10⁻⁵ (3.3)	% RUV (RSE,%)	16.4 (20.0); 14.1 (16.5)	23.4 (33.8); 7.1 (12.6)	22.0 (29.2); 12.6 (15.4)

Values from model independent experiments are the mean of 5 separate occasions in both transport directions from n = 2 to 3 filters per occasion for a total of 13 filters for each transport direction. Abbreviations: CV is coefficient of variation obtained from model independent analysis, RSE is the relative standard error of the estimate of the model-based parameter estimate; BOFV is between occasion and filter variability expressed as %; RUV is residual unexplained variability for apical (top) and basolateral (bottom) compartment CDF concentrations, respectively, expressed as %.