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Model-derived estimates of β-adjustment factor for enhancement of basolateral membrane clearance by MK-571 and glyceollin, and CDFDA hydrolysis clearance by genistein.
| Agent | Apical Dosing Parameter Estimates (% RSE) | Basolateral Dosing Parameter Estimates (% RSE) | ||
|---|---|---|---|---|
|
| ||||
| Clhydrolysis | Clcdf,bl | Clhydrolysis | Clcdf,bl | |
|
| ||||
| MK-571 | ---- | 1.7 × 10−2 (<0.1) | ---- | 2.4 × 10−2 (0.4) |
| Glyceollin | ---- | 2.2 × 10−2 (<0.1) | ---- | 1.8 × 10−2 (2.9) |
| Genistein | 6.9 × 10−3 (<0.1) | ---- | 2.8 × 10−2 (0.6) | ---- |
