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Synthesis of 1G244
Reagents and conditions: i. Isoindoline, HATU, DIEA, DMF, 0°C to r.t; ii. H 2, 10% Pd-C, MeOH; iii. 1-Bis(4-fluorophenyl)methyl piperazine, HATU, DIEA, DMF, 0°C to r.t, 75% for 3 steps; iv. 4N HCl in dioxane, 0°C to r.t, 90%.
