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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Clin Cancer Res. 2018 Feb 6;24(6):1375–1388. doi: 10.1158/1078-0432.CCR-17-2923

Fig. 4. Cholesterol biosynthesis inhibitors suppress proliferation of Ptch1+/− MB cells.

Fig. 4

(A–K) MB cells isolated from Ptch1+/− mouse were cultured in presence of vehicle (A) or simvastatin (B–D), triparanol (E), or together with WSC (F–J) for 48 hours, before cultured cells were immunostained against Ki67 (red) and counterstained with DAPI. Scale bars 10 μm.

(K) Percentage of Ki67 positive cells in cultured Ptch1+/− MB cells in presence of simvastatin, triparanol or with addition of WSC.

Significance asterisk key: p value < 0.05 (*), p<0.01 (**), p<0.001 (***), p<0.0001 (****).