Fig. 2.

Perifosine pretreatment decreases Akt and S6 activation long after KA-induced seizures. A Representative blots of Akt and S6 at different time intervals after KA-induced seizures. B Quantitative analysis showing that phosphorylation of Akt was increased from 3 h to 3 weeks after the onset of KA-induced seizures. There was a significant decrease of the p-Akt/Akt ratio compared to rats without perifosine pretreatment. C Quantitative analysis showing that phosphorylation of S6 was increased from 3 h to 3 weeks after the onset of KA-induced seizures. There was a significant decrease of the p-S6t/S6 ratio compared to rats without perifosine pretreatment. *P < 0.05, vs Veh + NS group, # P < 0.05 vs Veh + KA group, n = 6 rats/group.