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Perifosine pretreatment reduces mossy fiber sprouting after KA-induced seizures. A–F Representative Timm staining of mossy fiber sprouting in the DG (A–C) and CA3 (D–F) 6 weeks after KA-induced seizures (scale bars, 100 μm). G Quantitative analysis showing mild mossy fiber sprouting in perifosine-pretreated rats (*P < 0.05, vs Veh + NS group, # P < 0.05 vs Veh + KA group, n = 6/group).
