Table 1.
Summary of pharmacological data for NMDARs.
| GluN2A-WT | GluN2A-N447K | |
|---|---|---|
| Current density, pA/pF, (n)a | 143.0 ± 9.1 (25) | 174.1 ± 12.5 (22)* |
| Glutamate, EC50, μmol/L (n)a | 8.1 ± 0.9 (6) | 4.0 ± 0.4 (6)** |
| Mg2+, I-V (n)b | 61.5 ± 4.0% (9) | 72.1 ± 4.6% (11) |
| Mg2+, IC50, μmol/L (n)a | 28.6 ± 4.3 (6) | 48.9 ± 5.2 (6)* |
| Zn2+, IC50, nmol/L (n)a | 79.0 ± 6.5 (7) | 110.1 ± 15.8 (6) |
The data are expressed as mean ± SEM.
a At the holding potential of −60 mV.
b Percentage current remaining in the presence of 300 μmol/L MgCl2 at −30 mV.
* P < 0.05 compared with GluN2A-WT, unpaired t-test.
** P < 0.01 compared with GluN2A-WT, unpaired t-test.