Table 2.
Current density and glutamate EC50 values for NMDARs with alternative substitutions at GluN2A-N447.
| GluN2A-WT | GluN2A-N447K | GluN2A-N447A | GluN2A-N447E | |
|---|---|---|---|---|
| Current density, pA/pF, (n)a | 130.9 ± 9.7 (20) | 162.8 ± 8.6 (20)* | 128.7 ± 10.6 (14) | 133.0 ± 10.5 (14) |
| Glutamate EC50, μmol/L (n)a | 8.6 ± 0.8 (5) | 4.9 ± 0.5 (5)*** | 7.6 ± 0.4 (5) | 8.1 ± 0.6 (5) |
The data are expressed as mean ± SEM.
a At the holding potential of −60 mV.
* P < 0.05 compared with GluN2A-WT, one-way ANOVA.
*** P < 0.001 compared with GluN2A-WT, one-way ANOVA.