Fig. 2.

Effects of sub-chronic restraint stress and drug treatment on body weight, fur state, and plasma corticosterone levels after an acute stress challenge. A All groups of mice had comparable body weight. B Progression of fur quality during the stress and drug treatment procedures. Combined fluoxetine and melatonin treatment improved the fur state in stressed mice. C Either fluoxetine or melatonin administration alone or combined treatment reduced the plasma corticosterone levels at 30 min after the forced swim test. ***P < 0.001 versus CTL. ^## P < 0.01, ^### P < 0.001 versus SRS. n = 7 mice per group.