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Combined fluoxetine and melatonin treatment normalized BDNF–TrkB signaling in the hippocampus (A–B), but not in the prefrontal cortex (C–D). *P < 0.05, **P < 0.01, ***P < 0.001 vs CTL; # P < 0.05, ## P < 0.01 vs SRS group; n = 7 mice per group.
