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. 2018 Mar 16;7(Suppl 1):3–14. doi: 10.1007/s40121-018-0193-2

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — sEPCR levels and APACHE II score. Soluble endothelial protein C receptor (sEPCR) was quantified in blood samples harvested at ICU admission (within the first 24 h). a Patients were categorized according to APACHE II scores at admission. A cut-off value of 25 was used. b Patients with APACHE II score < 25 (N = 137) and c patients with APACHE II score ≥ 25 (N = 92) were further divided according to the presence of at least one H3 allele. Line in the box, median value; box edges, 25th to 75th centiles; whiskers, range of values. *p < 0.05; ****p < 0.0001 with the Mann-Whitney test