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. 2018 Mar 16;9:1105. doi: 10.1038/s41467-018-03443-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Structure, current SAR and route design plan for (+)-7-iso-JA-L-Ile (JA-Ile) and coronatine (1). a Structural similarities between the natural bioactive ligand JA-Ile and 1 are highlighted. Coronatine can be considered as comprising of two component parts; the bicyclic core, coronafacic acid 2, amino acid moiety, and coronamic acid 3. b, c A summary of the known SAR at the outset of this work. d Retrosynthesis and route design plan for SAR interrogation