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. 2018 Mar 16;8:4733. doi: 10.1038/s41598-018-23042-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Significant canonical pathways associated with differentially expressed genes in stretched neonatal ventricular myocytes. Ingenuity pathway analysis showing the canonical pathways that were most significant in the data sets of differentially expressed genes after (A) 1–12 and (B) 24–48 hours of mechanical stretch in cardiac myocytes. The entries that have a −log (p-value) greater than 1.3 and an absolute z-score value greater than 2 are displayed. Colors of the bars in the chart indicate their activation z-scores: orange, overall increase in the activity of the pathway; blue, decrease in activity. The intensity of the color indicates the degree of increase or decrease.