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. 2018 Mar 16;8:4733. doi: 10.1038/s41598-018-23042-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NRF2-mediated oxidative stress response –signaling in the nucleus. Significant canonical pathways associated with differentially expressed genes in response to 12 hours of mechanical stretch in neonatal rat ventricular myocytes are shown. Up- and down-regulated genes are displayed in red and green, respectively. The intensity of the color indicates the degree of up-regulation or downregulation. Genes are represented as various shapes that represent the functional class of the gene product. Full annotations for genes and molecules in this canonical pathway and whole figure of this canonical pathway are provided in Supplementary Datafile 1and Fig. S2, respectively.