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. 2018 Mar 16;8:4660. doi: 10.1038/s41598-018-23137-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MEF2A is the target gene of miR-19a-3p. (A) The predicted binding site of miR-19a-3p in 3′-UTR of MEF2A mRNA. (B and C) Expressions of miR-19a-3p and MEF2A mRNA by RT-PCR, using U6 and GAPDH as the internal control, respectively. n = 8, ^△p < 0.05 vs. sham-operation group, ^*p < 0.05 vs. model. (D) Detection of the interaction between miR-19a-3p and the 3′-UTR of MEF2A by dual-luciferase reporter assay. n = 8, ^△△p < 0.01 vs. NC. (E and F) MiR-19a-3p inhibited the protein expression of MEF2A after infection with miR-19a-3p mimic or miR-19a-3p inhibitor (anti- miR-19a-3p) as detected by WB analysis, using GAPDH as the internal control. n = 3, ^△△p < 0.01 vs. NC, ^**p < 0.01 vs. miR-19a-3p mimics.