Fig. 5.

ERα overexpression in NAc recapitulates the transcriptional signature of resilience in male mice. a Overview of RRHO. b The genes most strongly upregulated by ERα overexpression in the male NAc overlap with genes most strongly upregulated in this region of resilient mice after CSDS. c The male transcriptional signature of ERα overexpression is distinct from the transcriptional signature of CSDS susceptibility. d GO analysis of transcripts co-upregulated by ERα overexpression and the resilient phenotype after CSDS shows a positive enrichment for genes implicated in nervous system development and a negative enrichment for sensory perception genes. e ERα overexpression in the NAc of female mice induces a transcriptional pattern distinct from that induced by CVS. f ERα overexpression in male and female mice shows an overlap only in the most strongly downregulated genes. Genes upregulated by ERα overexpression, or moderately regulated in either direction by ERα, do not overlap. g GO analysis of transcripts co-downregulated by ERα in males and females indicates positive enrichment with immune-associated functions and underrepresentation of RNA metabolic processes