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. 2018 Mar 16;9(4):421. doi: 10.1038/s41419-018-0459-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Inhibition of JNK pathway either pharmacologically with its specific inhibitors (SP600125 and AS601245) or via siRNA resulted in a significant decrease in in vivo growth of GCT cell line (COV434) when xenografted subcutaneously into SCID mice (a, b). In line with these results, histopathological examination showed that there was a marked decrease in cellularity in the tumors with a concomitant decrease in the serum AMH level in the animals after JNK inhibitor treatment was given (c, d)