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. 2018 Mar 16;8:4670. doi: 10.1038/s41598-018-22843-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Apamin-sensitive SK currents in rabbit ventricular myocytes. (A) Representative current traces elicited from a holding potential of −55 mV using a family of voltage steps from −120 mV to +60 mV at 10 mV increments with 500 ms durations. Current traces shown are recorded in control (black traces, left panels), after 100 pM (blue traces), 10 nM (red traces), and 100 nM (green traces) of apamin (middle panels). Current traces in the right panels are apamin-sensitive currents obtained from digital subtraction. (B and C) Summary data for the current-voltage relationship of apamin-sensitive SK currents recorded from epicardial (Epi-) (n = 5) and endocardial (Endo-) (n = 7) ventricular myocytes.