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. 2018 Mar 16;8:4670. doi: 10.1038/s41598-018-22843-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activation of SK channels after depletion of the SR Ca²⁺ store. Activation of SK currents by Ca²⁺ influx through LTCCs in the presence of caffeine (A), ryanodine (B) and thapsigargin (C). The pipette solution contained 50 µM BAPTA. The insets in (A–C) show activation kinetics of the outward K⁺ currents (in pA, open symbols) compared to the total charge entered through LTCCs during the prepulse (Q_Ca in pC, closed symbols). (D) Summary data for the half-activation time under different conditions.