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. 2018 Mar 16;8:4715. doi: 10.1038/s41598-018-23036-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SEs are diversified in vivo. (A) SEs can be labelled in vivo by injection into the salivary glands, shown diagrammatically. (B) Specificity of SE labelling. Injection of M2-Cy3 into the right eye and PBS into the left eye shows exclusive signal in the ipsilateral (right) SCG but not the contralateral (left) SCG. (C) Bright antibody labelling is detected when M2-Cy3 is injected into the salivary gland of TrkA^FLAG/FLAG animals, but no label is observed when M2-Cy3 is injected into WT (non-FLAG) animals. (D) Close up imaging of single cells shows partial co-localization of in vivo SEs in the SCG with EEA1, Rab11, and Rab7. Scale bar 5 µm, inset scale bar 1 µm. (E) Quantification of SE co-localization with Rab proteins (n = 30–40 cells from 2 independent experiments).