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. 2018 Mar 16;9:1109. doi: 10.1038/s41467-018-03533-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Osmotic shock blocks flat-to-curved transition of CCSs. a Predicted ratio of flat (blue), dome (red) and pit (green) structures calculated from the binned AP2 and clathrin profiles of CME events (Fig. 6c) during osmotic shock for 1357 tracks. b Examples of CCSs under normal and osmotic shock conditions. Blue arrows point to flat structures. c Comparison of measured and predicted frequency of flat, dome and pit structures under normal and osmotic shock conditions. d Projected area distribution of the different clathrin morphologies under normal and osmotic shock conditions. A box /whisker plot of the projected area is shown in the inset. Mid-line represents median, cross represents the mean and the whiskers represent the 10 and 90 percentiles. e Comparison of projected area distributions of flat CCSs under normal and osmotic shock conditions. Results are calculated from four different membranes (number of CCSs per membrane: normal conditions 267, 308, 229 and 323; osmotic shock: 395, 99, 351 and 201); means with SD are shown