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. 2018 Mar 16;8:4734. doi: 10.1038/s41598-018-23107-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Descriptive statistics of corneal confocal microscopy (CCM) variables (A–E) (median with interquartile range and maximum/minimum). In general, values of all variables decrease with increasing severity of neuropathy. The sarcoidosis group was generally similar to the NDS (0–2) and (3–5) groups for NFD, NBD, NFL, NFA FIJI, but diverged for NFA WxL. (F) Percent reduction from the corresponding means of normal subjects for each CCM variable (error bars: SEM) illustrates that small nerve fiber losses range from 80% to 40% with increasing severity of neuropathy. [NFD = nerve fiber density; NBD = main nerve branch density; NFL = nerve fiber length; NFA WxL = nerve fiber area determined by length times average width; NFA FIJI = nerve fiber area determined by the the total number of pixels within the nerve plexus].