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. 2018 Mar 16;8:4734. doi: 10.1038/s41598-018-23107-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The relationship between NFL and NFA FIJI is characterized by a quadratic function. The change in slope of this curve shows that NFA changes more rapidly than NFL as nerve fiber densities approach normal (right portion of the curve). Conversely, differences bewteen these two variables are more similar in cases of severe neuropathy (left portion of the curve). (B) CCM data obtained using an independent (cross-validation) group of Type 2 diabetic subjects fall on the prediction curve from panel A.