Table 2.
The association between four SNPs genotypes and risk of breast cancer.
| SNPs | Genetic model | Genotype | Case (%) | Control (%) | P a | Adjusted OR(95%CI)b | P b |
|---|---|---|---|---|---|---|---|
| n = 484 | n = 484 | ||||||
| rs1942348 | 0.99 | ||||||
| Codominant | TT | 184(0.38) | 183(0.38) | 1 | |||
| CT | 227(0.47) | 227(0.47) | 0.91 (0.67–1.23) | 0.529 | |||
| CC | 73(0.15) | 74(0.15) | 0.99 (0.65–1.51) | 0.959 | |||
| Dominant | TT | 1 | |||||
| CT + CC | 300(0.62) | 301(0.62) | 0.93 (0.70–1.23) | 0.602 | |||
| Recessive | TT + TC | 411(0.85) | 410(0.85) | 1 | |||
| CC | 1.04 (0.71–1.54) | 0.827 | |||||
| Over-dominant | TT + CC | 257(0.53) | 257(0.53) | 1 | |||
| TC | 0.91 (0.69–1.20) | 0.507 | |||||
| Allele | T | 595(0.61) | 593(0.61) | 1 | 0.981 | ||
| C | 373(0.39) | 375(0.39) | 1.01(0.83–1.20) | ||||
| rs4801078 | 0.77 | ||||||
| Codominant | CC | 162(0.33) | 176(0.36) | 1 | |||
| CT | 211(0.44) | 238(0.49) | 0.95 (0.70–1.30) | 0.740 | |||
| TT | 111(0.23) | 70(0.15) | 1.79(1.20–2.68) | 0.005 | |||
| Dominant | CC | 1 | |||||
| CT + TT | 322(0.67) | 308(0.64) | 1.14 (0. 85–1.52) | 0.386 | |||
| Recessive | CC + CT | 373(0.77) | 414(0.85) | 1 | |||
| TT | 1.85 (1.28–2.66) | 0.001 | |||||
| Over-dominant | CC + TT | 273(0.56) | 246(0.51) | 1 | |||
| CT | 0.78 (0.59–1.02) | 0.078 | |||||
| Allele | C | 535(0.55) | 590(0.61) | 1 | 0.022 | ||
| T | 433(0.45) | 378(0.39) | 1.24(1.03–1.48) | ||||
| rs6420545 | 0.94 | ||||||
| Codominant | CC | 126(0.26) | 120(0.25) | 1 | |||
| CT | 228(0.47) | 236(0.49) | 0.88(0.63–1.24) | 0.462 | |||
| TT | 130(0.27) | 128(0.26) | 1.05 (0.72–1.54) | 0.794 | |||
| Dominant | CC | 1 | |||||
| CT + TT | 358(0.74) | 364(0.75) | 0.94(0.68–1.29) | 0.695 | |||
| Recessive | CC + CT | 354(0.73) | 356 (0.74) | 1 | |||
| TT | 1.14 (0.83–1.57) | 0.408 | |||||
| Over-dominant | CC + TT | 256(0.53) | 248 (0.51) | 1 | |||
| CT | 0.86 (0.65–1.13) | 0.282 | |||||
| Allele | C | 480(0.50) | 476(0.49) | 1 | 0.518 | ||
| T | 488(0.50) | 492(0.51) | 0.94(0.79–1.23) | ||||
| rs9636089 | 0.99 | ||||||
| Codominant | TT | 187(0.39) | 191(0.39) | 1 | |||
| CT | 223(0.46) | 226(0.47) | 0.90(0.66–1.21) | 0.475 | |||
| CC | 74(0.15) | 67(0.14) | 1.03 (0.67–1.58) | 0.896 | |||
| Dominant | TT | 1 | |||||
| CT + CC | 297(0.61) | 293(0.61) | 0.93 (0.70–1.23) | 0.596 | |||
| Recessive | TT + TC | 410(0.85) | 417(0.86) | 1 | |||
| CC | 1.09(0.74–1.62) | 0.661 | |||||
| Over-dominant | TT + CC | 261(0.54) | 258(0.53) | 1 | |||
| TC | 0.89 (0.67–1.18) | 0.408 | |||||
| Allele | T | 597(0.62) | 608(0.63) | 1 | 0.680 | ||
| C | 371(0.38) | 360(0.37) | 1.04(0.86–1.25) |
aPvalue of Hardy-Weinberg equilibrium in controls;
bP value of logistic regression analysis with adjusted for age, age at menarche, menopausal status, number of pregnancy and abortion, breast-feeding status, and family history of BC in first-degree relatives.