Table 3.
variables | case | control | rs6420545 | rs4801078 | rs1942348 | rs9636089 | ||||
---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) a | P a | OR (95%CI) a | P a | OR (95%CI) a | P a | OR (95%CI) a | P a | |||
TT vs CT + CC | CC vs CT + TT | CC vs CT + TT | TT vs CT + CC | |||||||
age | ||||||||||
≤50 | 302 | 285 | 0.70 (0.46–1.05) | 0.083 | 0.79(0.54–1.14) | 0.206 | 1.16(0.81–1.67) | 0.41 | 1.24 (0.87–1.78) | 0.238 |
>50 | 182 | 199 | 1.50(0.90–2.52) | 0.125 | 2.14 (1.33–3.45) | 0.002 | 0.60(0.37–0.99) | 0.045 | 0.57(0.35–0.92) | 0.021 |
Age at menarche | ||||||||||
≤13 | 152 | 201 | 0.95 (0.92–0.99) | 0.005 | 0.69(0.42–1.13) | 0.14 | 1.38(0.85–2.26) | 0.196 | 1.19(0.74–1.93) | 0.476 |
>13 | 332 | 283 | 1.46 (0.98–2.16) | 0.061 | 1.52(1.06–2.19) | 0.025 | 0.77(0.54–1.11) | 0.162 | 0.83(0.58–1.19) | 0.31 |
Age at menopause | ||||||||||
≤50 | 352 | 337 | 0.91(0.64–1.32) | 0.630 | 1.16 (0.83–1.62) | 0.4 | 1.01(0.72-0.1.42) | 0.946 | 1.03(0.74–1.44) | 0.85 |
>50 | 132 | 147 | 1.13 (0.58–2.19) | 0.726 | 1.13(0.62–2.06) | 0.68 | 0.67(0.38–1.20) | 0.18 | 0.66 (0.37–1.16) | 0.147 |
No. of pregnancy | ||||||||||
≤2 | 176 | 243 | 0.98 (0.58–1.66) | 0.95 | 1.32 (0.82–2.12) | 0.155 | 0.96(0.61–1.52) | 0.866 | 0.86 (0.55–1.35) | 0.512 |
>2 | 308 | 241 | 0.95(0.63–1.43) | 0.807 | 1.08 (0.74–1.59) | 0.679 | 0.89(0.61–1.31) | 0.577 | 0.96(0.66–1.41) | 0.848 |
No. of abortion | ||||||||||
≤2 | 417 | 438 | 0.95(0.68–1.33) | 0.776 | 1.16 (0.86–1.57) | 0.339 | 0.91(0.68–1.24) | 0.559 | 0.93(0.69–1.25) | 0.622 |
>2 | 67 | 46 | 1.10(0.44–2.73) | 0.843 | 1.13(0.46–2.77) | 0.784 | 0.86(0.37–2.02) | 0.729 | 0.84(0.36–1.98) | 0.691 |
Breast-feeding | ||||||||||
no | 27 | 42 | 46.67 (2.46–884.21) | 0.010 | 18.72(1.17–300.7) | 0.039 | 0.56(0.16–1.96) | 0.366 | 0.60(0.17–2.11) | 0.422 |
yes | 457 | 442 | 0.89 (0.64–1.23) | 0.473 | 1.11 (0.82–1.49) | 0.513 | 0.95(0.71–1.28) | 0.735 | 0.94(0.70–1.27) | 0.696 |
Family history | ||||||||||
no | 462 | 463 | 1.01(0.73–1.40) | 0.947 | 1.21(0.90–1.64) | 0.212 | 0.92(0.69–1.24) | 0.599 | 0.90 (0.67–1.21) | 0.473 |
yes | 22 | 21 | 0.29(0.05–1.55) | 0.147 | 0.52(0.10–2.80) | 0.448 | 0.65(0.14–2.92) | 0.573 | 1.33 (0.31–5.77) | 0.701 |
aPvalue of logistic regression analysis with adjusted for age, age at menarche, menopausal status, number of pregnancy and abortion, breast-feeding status, family history of BC in first-degree relatives(the stratified factor in each stratum excluded).