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. 2018 Mar 16;8:4680. doi: 10.1038/s41598-018-22881-x

Table 3.

Stratification analysis of the fiveSNPs and BC susceptibility.

variables case control rs6420545 rs4801078 rs1942348 rs9636089
OR (95%CI) a P a OR (95%CI) a P a OR (95%CI) a P a OR (95%CI) a P a
TT vs CT + CC CC vs CT + TT CC vs CT + TT TT vs CT + CC
age
  ≤50 302 285 0.70 (0.46–1.05) 0.083 0.79(0.54–1.14) 0.206 1.16(0.81–1.67) 0.41 1.24 (0.87–1.78) 0.238
  >50 182 199 1.50(0.90–2.52) 0.125 2.14 (1.33–3.45) 0.002 0.60(0.37–0.99) 0.045 0.57(0.35–0.92) 0.021
Age at menarche
  ≤13 152 201 0.95 (0.92–0.99) 0.005 0.69(0.42–1.13) 0.14 1.38(0.85–2.26) 0.196 1.19(0.74–1.93) 0.476
  >13 332 283 1.46 (0.98–2.16) 0.061 1.52(1.06–2.19) 0.025 0.77(0.54–1.11) 0.162 0.83(0.58–1.19) 0.31
Age at menopause
  ≤50 352 337 0.91(0.64–1.32) 0.630 1.16 (0.83–1.62) 0.4 1.01(0.72-0.1.42) 0.946 1.03(0.74–1.44) 0.85
  >50 132 147 1.13 (0.58–2.19) 0.726 1.13(0.62–2.06) 0.68 0.67(0.38–1.20) 0.18 0.66 (0.37–1.16) 0.147
No. of pregnancy
  ≤2 176 243 0.98 (0.58–1.66) 0.95 1.32 (0.82–2.12) 0.155 0.96(0.61–1.52) 0.866 0.86 (0.55–1.35) 0.512
  >2 308 241 0.95(0.63–1.43) 0.807 1.08 (0.74–1.59) 0.679 0.89(0.61–1.31) 0.577 0.96(0.66–1.41) 0.848
No. of abortion
  ≤2 417 438 0.95(0.68–1.33) 0.776 1.16 (0.86–1.57) 0.339 0.91(0.68–1.24) 0.559 0.93(0.69–1.25) 0.622
  >2 67 46 1.10(0.44–2.73) 0.843 1.13(0.46–2.77) 0.784 0.86(0.37–2.02) 0.729 0.84(0.36–1.98) 0.691
Breast-feeding
  no 27 42 46.67 (2.46–884.21) 0.010 18.72(1.17–300.7) 0.039 0.56(0.16–1.96) 0.366 0.60(0.17–2.11) 0.422
  yes 457 442 0.89 (0.64–1.23) 0.473 1.11 (0.82–1.49) 0.513 0.95(0.71–1.28) 0.735 0.94(0.70–1.27) 0.696
Family history
  no 462 463 1.01(0.73–1.40) 0.947 1.21(0.90–1.64) 0.212 0.92(0.69–1.24) 0.599 0.90 (0.67–1.21) 0.473
  yes 22 21 0.29(0.05–1.55) 0.147 0.52(0.10–2.80) 0.448 0.65(0.14–2.92) 0.573 1.33 (0.31–5.77) 0.701

aPvalue of logistic regression analysis with adjusted for age, age at menarche, menopausal status, number of pregnancy and abortion, breast-feeding status, family history of BC in first-degree relatives(the stratified factor in each stratum excluded).