Table 4.
The Associations between four SNPs and ER, PR and HER-2 Status of Breast Cancer Patients.
| genotypes | ER | P a | OR (95%CI)a | PR | P a | OR (95%CI)a | Her-2 | P a | OR (95%CI)a | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative (n = 149) | Positive (n = 293) | Negative (n = 188) | Positive (n = 253) | Negative (n = 120) | Positive (n = 308) | |||||||
| rs6420545 | ||||||||||||
| CC | 40 | 78 | 1 | 55 | 63 | 1 | 36 | 77 | 1 | |||
| CT | 64 | 137 | 0.389 | 1.26 (0.75–2.13) | 75 | 125 | 0.051 | 0.66 (0.99–2.76) | 53 | 144 | 0.402 | 1.27(0.73–2.22) |
| TT | 45 | 78 | 0.826 | 0.94 (0.53–1.65) | 58 | 65 | 0.957 | 0.99(0.57–1.70) | 31 | 87 | 0.313 | 1.38(0.74–2.58) |
| rs4801078 | ||||||||||||
| CC | 54 | 110 | 1 | 71 | 82 | 1 | 45 | 102 | 1 | |||
| CT | 61 | 123 | 0.770 | 1.08 (0.66–1.77) | 75 | 109 | 0.145 | 1.43 (0.88–2.04) | 46 | 134 | 0.478 | 1.22 (0.71–2.09) |
| TT | 34 | 70 | 0.774 | 1.09(0.62–1.92) | 42 | 62 | 0.370 | 1.28(0.74–2.21) | 29 | 72 | 0.713 | 1.12(0.61–2.07) |
| rs1942348 | ||||||||||||
| TT | 59 | 110 | 1 | 75 | 94 | 1 | 48 | 117 | 1 | |||
| CT | 64 | 140 | 0.361 | 1.25 (0.78–2.01) | 78 | 125 | 0.183 | 1.37 (0.86–2.16) | 55 | 144 | 0.789 | 0.93 (0.56–1.57) |
| CC | 26 | 43 | 0.761 | 0.91 (0.49–1.69) | 35 | 34 | 0.344 | 0.75 (0.41–1.36) | 17 | 47 | 0.723 | 0.88(0.45–1.75) |
| rs9636089 | ||||||||||||
| TT | 61 | 113 | 1 | 76 | 98 | 1 | 48 | 118 | 1 | |||
| CT | 63 | 137 | 0.301 | 1.28(0.80–2.05) | 78 | 121 | 0.276 | 1.28(0.82–2.02) | 55 | 142 | 0.936 | 0.98(0.59–1.63) |
| CC | 25 | 43 | 0.932 | 1.03(0.55–1.92) | 34 | 34 | 0.475 | 0.80(0.44–1.47) | 17 | 48 | 0.935 | 1.03(0.51–2.06) |
aP value of logistic regression analysis with adjusted for age, age at menarche, menopausal status, number of pregnancy and abortion, breast-feeding status, family history of BC in first-degree relatives.