Table 5.

Results for child autistic symptoms, ADHD and comorbid disorders

Study, antidepressants studied	Child age at testing (years)	Outcome	Effect size	95% CI	N	Adjustments/exclusions/stratification
Child autistic symptoms
El Marroun et al. (2012), SSRI	6	2. Autistic symptoms	0.10	− 0.32, 0.52	272	b, c, d, e, h, i, p
		3a. Social cognition	0.08	− 0.36, 0.52	272	b, c, d, e, h, i, p
		3b. Social communication	0.12	− 0.36, 0.60	272	b, c, d, e, h, i, p
		3c. Autistic mannerisms	0.08	− 0.31, 0.47	272	b, c, d, e, h, i, p
			Effect ratio
Child ADHD and comorbid disorders
Nulman et al. (2012), venlafaxine	3–7	4a. Total problems	4.65	0.53, 41.1	116	g
SSRI			11.4	1.42, 91.8	116	g
Venlafaxine		4b. DSM total symptoms	0.85	0.28, 2.61	116	g
SSRI			0.85	0.28, 2.61	116	g

Estimates in bold are statistically significant. Effect ratio is on log odds scale. a. Maternal mental health pre-birth, b. maternal mental health at some point after delivery, c. maternal age, d. socio-economic status, e. smoking in pregnancy, f. alcohol in pregnancy, g. other psychoactive drug and/or medication use during pregnancy, h. sex of child, i. gestational age, j. age of child at testing, k. APGAR scores, l. breastfeeding, m. problems during pregnancy, n. mother-child connection, o. postnatal difficulties, p. ethnicity, q. exposure window

SSRI selective serotonin reuptake inhibitors, CI confidence interval