Fig. 4.

a SLCO1B1 c.521T>C genotyped pitavastatin pharmacokinetic time courses in the Korean population. Blue circles and lines represent data and simulations for the wild type (i.e., SLCO1B1 c.521TT). Red triangles and lines represent data and simulations for homogenous mutations (i.e., SLCO1B1 c.521CC). Shaded areas indicate 95% confidence intervals approximated with parameter values generated in Markov chain Monte Carlo. b Prospectively predicted ungenotyped pharmacokinetic time courses of pitavastatin in Caucasian populations. Circles, line, and shaded area represent observation, mean prediction, and confidence interval. c Predicted ungenotyped pharmacokinetic time courses of pitavastatin in Caucasian (black) and Japanese (green) populations