| Atherosclerosis |
Adults |
A/E |
Most common cause of ACAD in adults. Clinical importance depends on association with significant coronary artery stenosis |
| Kawasaki disease |
Childhood and adolescence |
A |
Most common cause in children and adolescents, and in the Far East |
| Inflammatory disorders |
Young adults |
E |
Takayasu arteritis, systemic lupus, Behcet syndrome, polyarteritis nodosa, Reiter syndrome, psoriatic arthritis, Wegner granulomatosis, Churg-Strauss syndrome |
| Fistula |
Any age |
E |
Compensatory dilatation secondary to high flow state |
| Coronary anomalies |
Any age |
E |
Compensatory dilatation secondary to myocardial ischemia |
| Connective tissue disorders |
Young adults |
E |
Marfan syndrome, Ehlers-Danlos syndrome, cystic medial necrosis |
| Mycotic |
Any age |
A |
Infection, most commonly with staph aureus with microemboliztion to vasa vasorum or invasion of vessel wall |
| Trauma/iatrogenic |
Adults |
A |
As a result of coronary interventions |
| Cocaine |
Adult |
A |
Direct endothelial damage form episodic hypertension, vasoconstriction, and underlying atherosclerosis |
