Fig. 1.

Outline of the screening strategy identifying the RBP SORBS2 as a key suppressor of metastatic colonization of ovarian cancer. a Venn diagram outlining the meta-analysis of key RBPs essential for ovarian cancer aggressiveness. b Genomic alterations of the top scored RBP genes in TCGA ovarian cancer dataset. c Relative migration ability of ovarian cancer cells treated with siRNAs of four significantly downregulated RBPs in TCGA ovarian cancer dataset. d Kaplan-Meier analysis of SORBS2 expression and clinical outcome of ovarian cancer in the Australian Ovarian Cancer Study (AOCS) dataset. e Gene set enrichment analysis (GSEA) plots showing enrichment of the TGF-β program and the cell adhesion program in different genes between SORBS2 high and SORBS2 low groups in TCGA dataset. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001