Table 8.
Receiver operator characterization of TMKmt Ag and host specific IgG EIA-ODs for detecting TB exposure and or disease status among HIV positive individuals
| Among HIV positive individuals | Active TB vs OD values classification | |
|---|---|---|
| % (95% CI) | ||
| ATB vs No TB | ATB vs (LTBI & No TB) | |
| TMKmt Ag Capture | ||
| n | 128 | 220 |
| Prevalence | 80.0 (73.0,86.9) | 63.0 (56.0,69.1) |
| Sensitivity | 99.0 (94.7,100.0) | 73.9 (65.8,81.0) |
| Specificity | 68.0 (46.5,85.1) | 90.2 (81.7,95.7) |
| PPV | 92.7 (86.2,96.8) | 92.7 (86.2,96.8) |
| NPV | 94.4 (72.7,99.9) | 67.3 (57.7,75.9) |
| ROC area | 83.5 (74.1,92.9) | 82.1 (77.2,87.0) |
| TMKmt Ab Capture | ||
| n | 154 | 167 |
| Prevalence | 74.0 (68.0, 81.9) | 72.0 (65.0,79.1) |
| Sensitivity | 96.6 (91.4, 99.1) | 92.6 (86.3,96.5) |
| Specificity | 21.1 (9.5, 37.3) | 34.8 (21.4,50.2) |
| PPV | 78.9 (71.2,85.3) | 78.9 (71.2,85.3) |
| NPV | 66.7 (34.9,90.1) | 64.0 (42.5,82.0) |
| ROC | 58.8 (52.0,65.6) | 63.7 (56.3,71.0) |