Table 2.
Primary and secondary endpoints
| Measurement | Site | Time (months) | |
|---|---|---|---|
| Primary endpoints | |||
| Δ Bone mineral density | DXA | Total hip Spinal region |
12 |
| Secondary endpoints | |||
| Δ Bone mineral density | DXA | Total hip Spinal region |
6, 18, and 24 |
| Δ Bone microarchitecture | HR-pQCT | Distal radius Distal tibia |
6, 12, 18, and 24 |
| Δ Bone biomarkers | P1NP CTX, sclerostin |
Serum | 3, 6, 12, 18, and 24 |
| Δ Physical biomarkers | TUG SPPB |
3, 6, 12, 18, and 24 | |
| Dynamometer | Hand grip | ||
| Nottingham power rig | Leg extensor | ||
| Δ Quality of life | EQ-5D | 12 and 24 | |
| Δ Fear of falling | FES-I | 12 and 24 | |
| Physical activity | IPAQ | 0, 12, and 24 | |
| Adherence to WBV | Training logbook | Continuously | |
| Falls | Falls calendar | Continuously | |
Δ change from baseline; Time is measured in months; DXA dual-energy x-ray absorptiometry; HR-pQCT high-resolution peripheral quantitative computed tomography; P1NP procollagen type-1 amino-terminal propeptide; CTX carboxy-terminal type-1 collagen crosslinks; TUG Timed Up and Go; SPPB Short Physical Performance Battery; FES-I Falls Efficacy Scale International; IPAQ The International Physical Activity Questionnaire; EQ-5D EuroQoL 5-dimension, 5-level questionnaire, WBV whole-body vibration