Table 1.
Correlations between clinicopathological parameters and FOXP1 expression in neoplastic and stromal compartments of primary tumor
| Clinical parameters | FOXP1 immunoreactivity
|
|||||
|---|---|---|---|---|---|---|
| Tumor cells
|
Stromal cells
|
|||||
| Low (n=54) | High (n=42) | p-value | Absent (n=18) | Present (n=78) | p-value | |
| Age (21–79 years); mean=56.58±15.45; median=58.00 | 56.52±16.43; 59.50 | 56.88±14.29; 59.50 | 0.9205a | 55.22±15.88; 58.00 | 57.12±15.44; 58.00 | 0.6898a |
| Gender | ||||||
| Female | 20 (37.04) | 19 (45.24) | 0.4173b | 5 (27.78) | 34 (43.59) | 0.2902c |
| Male | 34 (62.96) | 23 (54.76) | 13 (72.22) | 44 (56.41) | ||
| pT location | ||||||
| Head/neck | 2 (3.70) | 1 (2.38) | 0.4443d | 1 (5.56) | 2 (2.56) | 0.3401d |
| Extremities | 26 (48.15) | 15 (35.71) | 9 (50.00) | 32 (41.03) | ||
| Hand/foot | 6 (11.11) | 8 (19.05) | 4 (22.22) | 10 (12.82) | ||
| Trunk | 20 (37.04) | 18 (42.86) | 4 (22.22) | 34 (43.59) | ||
| pT | ||||||
| pT1 | 25 (46.30) | 9 (21.43) | 0.0440e | 1 (5.56) | 33 (42.31) | 0.0015e |
| pT2 | 10 (18.52) | 8 (19.05) | 4 (22.22) | 14 (17.95) | ||
| pT3 | 7 (12.96) | 16 (38.10) | 5 (27.78) | 18 (23.08) | ||
| pT4 | 12 (22.22) | 9 (21.43) | 8 (44.44) | 13 (16.67) | ||
| Regional lymph nodes status (pN) | ||||||
| No metastases (pN−) | 52 (96.30) | 29 (69.05) | 0.0003c | 12 (66.67) | 69 (88.46) | 0.0326b |
| Metastases present (pN+) | 2 (3.70) | 13 (30.95) | 6 (33.33) | 9 (11.54) | ||
| Distant metastases (pM) | ||||||
| No metastases (pM−) | 53 (98.15) | 38 (90.48) | 0.1645c | 15 (83.33) | 76 (97.44) | 0.1546c |
| Metastases present (pM+) | 1 (1.85) | 4 (9.52) | 3 (16.67) | 2 (2.56) | ||
| SNLB status (55 patients) | ||||||
| No metastases (SNLB−) | 32 (96.97) | 13 (59.09) | 0.0006c | 5 (62.50) | 40 (85.11) | 0.1492c |
| Metastases present (SNLB+) | 1 (3.03) | 9 (40.91) | 3 (37.50) | 7 (14.89) | ||
Notes: Data presented as mean ± SD; median or n (%).
a
p-value of the Mann–Whitney U-test;
b
p-value of the Pearson’s χ2 test;
c
p-value of the Fisher’s exact test;
d
p-value of the Freeman–Halton extension of the Fisher’s exact probability test;
e
p-value of the Cochran–Armitage test for trend; statistically significant results (p<0.05) are given in bold.
Abbreviations: pT, primary tumor; SLNB, sentinel lymph node biopsy.