Table 2.
Correlations between histological characteristics of melanoma primary tumors and FOXP1 expression in neoplastic and stromal compartments
| Histopathological parameters | FOXP1 immunoreactivity
|
|||||
|---|---|---|---|---|---|---|
| Tumor cells
|
Stromal cells
|
|||||
| Low (n=54) | High (n=42) | p-value | Absent (n=18) | Present (n=78) | p-value | |
| Breslow thickness (mm) | 1.20 (0.70–4.00) | 2.50 (1.20–4.00) | 0.0649a | 3.85 (2.00–6.00) | 1.80 (0.75–4.00) | 0.0021a |
| Clark level | ||||||
| I | 0 (0.00) | 0 (0.00) | 0.0529b | 0 (0.00) | 0 (0.00) | 0.0112b |
| II | 14 (25.93) | 3 (7.14) | 2 (11.11) | 15 (19.23) | ||
| III | 24 (44.44) | 22 (52.38) | 5 (27.78) | 41 (52.56) | ||
| IV | 12 (22.22) | 12 (28.57) | 7 (38.89) | 17 (21.79) | ||
| V | 4 (7.41) | 5 (11.90) | 4 (22.22) | 5 (6.41) | ||
| Histological type | ||||||
| Superficial spreading melanoma | 38 (70.37) | 26 (61.90) | 0.5673c | 9 (50.00) | 55 (70.51) | 0.2601c |
| Nodular malignant melanoma | 14 (25.93) | 15 (35.71) | 8 (44.44) | 21 (26.92) | ||
| Acral lentiginous melanoma | 2 (3.70) | 1 (2.38) | 1 (5.56) | 2 (2.56) | ||
| Mitotic rate | ||||||
| 0 | 28 (51.85) | 16 (38.10) | 0.1796d | 5 (27.78) | 39 (50.00) | 0.1171e |
| ≥1 | 26 (48.15) | 26 (61.90) | 13 (72.22) | 39 (50.00) | ||
| Ulceration | ||||||
| No | 34 (62.96) | 18 (42.86) | 0.0640e | 5 (27.78) | 47 (60.26) | 0.0177e |
| Yes | 20 (37.04) | 24 (57.14) | 13 (72.22) | 31 (39.74) | ||
| TILs | ||||||
| No | 8 (14.81) | 9 (21.43) | 0.2533c | 4 (22.22) | 13 (16.67) | 0.5749c |
| Nonbrisk | 15 (27.78) | 16 (38.10) | 7 (38.89) | 24 (30.77) | ||
| Brisk | 31 (57.41) | 17 (40.48) | 7 (38.89) | 41 (52.56) | ||
| Microsatellitosis | ||||||
| No | 50 (92.59) | 41 (97.62) | 0.3818e | 16 (88.89) | 75 (96.15) | 0.2346e |
| Yes | 4 (7.41) | 1 (2.38) | 2 (11.11) | 3 (3.85) | ||
| Tumor regression | ||||||
| No | 52 (96.30) | 37 (88.10) | 0.2340e | 15 (83.33) | 74 (94.87) | 0.1195e |
| Yes | 2 (3.70) | 5 (11.90) | 3 (16.67) | 4 (5.13) | ||
Notes: Data presented as median (1: quartile–3: quartile) or n (%).
a
p-value of the Mann–Whitney U-test;
b
p-value of the Cochran–Armitage test for trend;
c
p-value of the Freeman–Halton extension of the Fisher’s exact probability test;
d
p-value of the Pearson’s χ2 test;
e
p-value of the Fisher’s exact test; statistically significant results (p<0.05) are given in bold.
Abbreviation: TILs, tumor-infiltrating lymphocytes.