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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Exp Hematol. 2017 Dec 26;60:1–9. doi: 10.1016/j.exphem.2017.12.008

Figure 1. HSC-independent waves of embryonic hematopoiesis contribute to self-maintaining, tissue-resident populations of innate-type immune cells in adult tissues.

Figure 1

This includes microglia in the adult brain derived from primitive macrophage progenitors, tissue-resident macrophages (Kupffer cells, alveolar macrophages, and Langerhans cells) of the liver, lungs, and skin derived from erythromyeloid progenitors (EMP), some B-1a cells residing in the peritoneal and pleural cavities derived from embryonic B cell progenitors and/or lymphomyeloid progenitors (LMP), and some γδ T cells, including the subset of dendritic epidermal T cells (DETC), in skin and intestines derived from embryonic T cell progenitors and/or LMP. *It remains uncertain as to whether the earliest innate-type lymphoid wave is derived from the same lineage of hemogenic endothelium that later gives rise to HSC and/or from a distinct lineage of hemogenic endothelium (see Figure 2).