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Proteus syndrome. Confluent papules and nodules are a cerebriform connective tissue nevus (CCTN) precursor lesion. A, Confluent papules and nodules cover the majority of the sole at baseline, then eventually become replaced by CCTN over time. B, The confluent papules and nodules decreased with age, most prominently in younger individuals. C, The concurrent increase in total lesional area (p<.0001 in children) suggests conversion into CCTN.
