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Proteus syndrome. The center of cerebriform connective tissue nevus (CCTN) overlapped in pediatric patients. Each child with a CCTN that occupied 20% or less of the sole on initial image was assigned a unique color. The area proximal to the ball of the foot appears to be the point of convergence of the center of most CCTNs. We hypothesize that mechanical stress from pressure or stretch is a contributing factor in lesion formation.
