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. 2018 Mar 4;2018:9536406. doi: 10.1155/2018/9536406

Figure 5.

Figure 5

The involvement of various nonopioid receptor antagonists on MECN-induced antinociception in the acetic acid-induced abdominal constriction test in mice. Yohimbine (YOH; 0.15 mg/kg, i.p.), pindolol (PDL; 1 mg/kg, i.p.), caffeine (CAF; 3 mg/kg, i.p.), and haloperidol (HAL; 0.2 mg/kg; i.p.) were administrated 15 min before vehicle (10 mL/kg, p.o.) or MECN (500 mg/kg, p.o.). Each column represents the mean ± SEM of six mice. Statistical analyses were performed using 1-way ANOVA followed by Dunnett's post hoc test. ∗∗∗p < 0.001 compared to the control group. #p < 0.05 and ###p < 0.001 compared to 500 mg/kg MECN-treated group.