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hucMSC-Ex reduced oxidative stress in mouse liver tumor. (a, b) The levels of 8-OHdG, SOX9, and collagen in mouse livers were measured by immunohistochemistry or Sirius red staining in liver tumor treated with PBS or hucMSC-Ex. Original magnification 200x. Compared with the PBS group, hucMSC-Ex significantly reduced production of oxidative stress marker 8-OHdG, SOX9 expression, and collagen deposition in liver tumor (n = 6; ∗∗P < 0.01, ∗∗∗P < 0.001).
